Recommended Dose: Take 1 tablet twice daily or as directed by your healthcare practitioner. Recommended Use: Helps to reduce homocysteine levels to support cardiovascular health. Caution: Consult a healthcare practitioner prior to use if you are pregnant, breastfeeding, taking medications or sulfonamides. Hypersensitivity has been known to occur; in which case, discontinue use. People sensitive to nicotinic acid may experience flushing of the skin that is generally mild and transient. Do not use if perma seal is missing. This product is non-GMO, gluten-free, and vegetarian.